Gabapentin And Tramadol – Understanding The Consequences [SIMPLE ANSWERS]

Many different people are hooked on pain medications.

When these individuals cannot achieve their desired high, they’ll go to extreme measures to try and do so. Some will even attempt to mix two or more medications.

This could be incredibly dangerous and could result in some frightening side effects.

 This is especially true when it comes to mixing Gabapentin and Tramadol.

Within this guide, you’ll learn about the dangers of this combination.

Enhanced Side Effects

Before mixing these two drugs, you should realize that doing so would enhance each side’s side effects.

Below, you will find a list of these side effects.

  • Complications concentrating
  • Lethargy and drowsiness
  • Increased dizziness
  • Impaired judgment and thinking

Now, these side effects aren’t classified as dangerous, but they could be in certain situations.

Consuming both drugs and driving a vehicle would be incredibly unwise.

When consuming the combination together or one drug separately, you should refrain from driving a vehicle or operating any machinery type.

The Risk Of The Interaction

When exploring Tramadol and Gabapentin’s interaction, you should realize that the drug interaction is classified as moderate.

Although the risks aren’t as dangerous as many others, the combination should not be used unless a doctor instructs you to do so.

The risks are ultimately too dangerous and could easily put you in harm’s way.


As a whole, it is not recommended to consume these two substances together.

The risks involved could put you in unnecessary danger, and the effects will be enhanced.

Therefore, you should prevent yourself from combining the drugs, unless a reliable doctor tells you to do so.

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David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others. David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.


  1. So far my experience with adding tramadol to my gabapentin for better pain control has just led to extreme sleepiness and impaired concentration. I can’t even stay awake to make meals half the time. This is very discouraging. My dose of tramadol is 25 mg in the evening, with gabapentin at 300 mg in the evening. Then I take gabapentin 300 mg in the morning along with 2.5 mg oxycodone. That is all I take. This is not fun to be so tired that I cannot do anything. Before adding even this small dose of tramadol I was not overly sedated at all. I was hoping the tramadol would help with my pain from radiation treatments. I didn’t want to take any more oxycodone as I had cut back on it due to constipation problems and thought tramadol might be the solution as a substitute for the oxycodone I had been taking in the evening for my pain. With keeping my dose of oxycodone at 2.5 mg a day and using tramadol at night, my pain is better and my constipation has resolved, but it seems my lymphedema has gotten worse all over again since switching to tramadol in the evenings. The lymphedema (apparently from radiation damage to lymph notes) is getting unbearable. Can this much sluggishness and lymphedema be caused by tramadol, or tramadol in addition to gabapentin? Would be interested in any professional input on this matter.

  2. I have been on 3,600mg of gabbapentin per day for two years, and 325/37.5mg Tramacet(Tramadol), 8 per day for the last year, and 8 t3’s per day before that, I would rather go back to just over two years ago of being healthy, still no answers from doctors on unexplained blisters that look like burn marks on my legs that cause me severe pain, you’d think in today’s day and age and technology there would be an answer, but it seems as though they just keep us high on expensive prescription meds and I haven’t felt any closer to the truth on my problem in a long time. These drugs keep me from doing my job properly, I’m cloudy in my thinking and still in pain and yet if I don’t take them I’m in so much pain that I can’t walk, and yet every test, blood, MRI, Dermatologist, Neurologist, Biopsy, all my tests say I’m 100% healthy.

  3. Certain people can drives drunk/drugged and don’t have accident, so are you saying it’s ok to drive drunk/drugged? You need to understand that your case is not a generality. Thank you for sharing your opinion, it seems that you take a lot of medication and your brain has probably develop a tolerance after all this time but do not be unconscious you are not at the shelter of an accident.

  4. I find this article incredibly inaccurate.

    I myself take 400mg of Tramadol, and 3600mg of Gabapentin, every day, and have done so for the last 4 years.
    Along with 75mg of Diclofenac from time to time.
    I have also driven my car, almost every day of that 4 years, along with my truck, forklift, and front end loader at work.

    This articles does not state you “may” or may not, have these side effects. Merely that this combination amplifies all of them, implying that you will experience all of them.

    I myself experience none of them, never experienced any major sifde effect of any of my medications.

    So I find this statement to be incredibly inaccurate.
    ***Now, these side effects aren’t classified as dangerous, but they could be in certain situations. Consuming both drugs and driving a vehicle would be incredibly unwise. When consuming the combination together or one drug separately, you should refrain from driving a vehicle or operating any type of machinery.****

    Anyway, just my 2c.

  5. I totally agree with the ĺast comment. I take same
    Combination with the great relief of pain at night

  6. agree with Abby I have Lupus and fibro and am stuck with very mild pain meds that don’t help me on a “good ” day because Drs. are so scared to allow patients to actually feel “good.” It’s ridiculous and out of hand.

  7. It’s troubling that the medical community responds this way to anything that has feeling of well-being as a side affect. This combination when taken at moderate doses gives a “high” or very pleasant feeling. Doctors have an instinctual recoil for an individual to experience this. (Nobody should be allowed to have a euphoric feeling..that is a bad thing)

    Frankly, I’m tired of this community firing off statements with bold type with no explanation. (“The risks are too dangerous and could put you in harms way”) I showed this page to my doctor and his reply was..”what harm? explanation would be nice because this combination is the best one I know to replace harder narcotics.. My peers and the government have really rammed this pain pill paranoia down the publics throat..and I no longer take any of it seriously. The day they took Darvocett away it affected my ability to manage pain safely. Now they’re on about this..give me a break.”

    Here’s the raw truth: this combination produces a very pleasant euphoric feeling. The over all feeling among these communities is that euphoria is a bad thing and should be discouraged. The fact is this combination is safe. It’s much safer than heavy narcotics and works just as well. Abuse potential is always there when a drug or combination of drugs “feel good.” You don’t make decisions simply based on the lowest common denominator or in other words, you don’t make a decision for a patient you know based on what a drug addict might do.

    Again..this combination is safe and effective. I think today’s elite doctors would have everybody on a dangerous NSAID that damages heart tissue, rather than “allowing” a patient to possibly “feel good.” My 83 year old mother cannot get anything for her massive pain because of the fear her doctor has of giving anything narcotic to anybody.. Her doctor has a policy-“absolutely no narcotic pain meds are given for any reason.” Now, that’s a horrible policy and an unnecessary one.

    Now we have this nosy bunch striking fear of these effective meds that are now being given because of the “no narcotic anything” culture we live in. It always happens-if a product or product grouping starts being noticeably given more…there will always be a group of “medical professionals” popping up somewhere to first “warn”..then next they always create a news story out of it for “awareness” ..then it always turns into a “crisis” and it has to be “stopped.” I think the idea is to push doctors to give Celebrex or one of the new NSAID products big pharma has had little luck with being the “go-to” pain killers. My doctor said the risk of much worse events are likely on these drugs then any narcotic.. The risk of heart attack is huge with prescription NSAIDs and I will not give them.”

    So I take this with a grain of salt.. Tramadol and Gabapentin is a fantastic combination and works incredibly well in relieving pain..and yes, it does have a very euphoric feeling of well being.. Sorry docs, but there is no reason to fear a patient experiencing euphoria with the relieving of pain. And all of this from a very low dose of a synthetic opioid and an anti-seizure med. Either explain yourself with your opinions or stop giving them.

  8. Is there a minimum or maximum time between taking Tramadol and gabapentin for instance tramadol at 4:30pm and gabapentin at 11:30pm.
    Bob Becker

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