Tramadol And Oxycodone – All You Should Know About Mixing [QUICK ANSWERS]

There are millions of individuals all around the globe that suffer from chronic pain. Many of these people turn towards prescription medications as a way to alleviate their suffering.

Some people suffer from terrible pain, which doesn’t dissipate, after consuming a single medication. This has led many to mix pain relief medications to return to normal, but this isn’t always safe or effective.

Within this guide, you’ll learn about mixing Tramadol and Oxycodone.

About Tramadol

When it comes down to it, Tramadol, also known as Ultram, is a moderate pain reliever with very few side effects. Tramadol is prescribed to the patient when pain is acute, and more potent medications aren’t needed. Also, if the user is allergic to opiates, Tramadol is usually the most common alternative.

About Oxycodone

Oxycodone is much stronger. It is a Schedule II opiate, which comes with many different side effects. When compared to Tramadol, Oxycodone is much more dangerous. Oxycodone can be effective and safe if used only for a short period and only as your medical professional recommends.

Mixing Tramadol And Oxycodone

If you are considering mixing these two medications, you shouldn’t. Although this won’t necessarily present you with added dangers, it is somewhat purposeless.

As someone, which is prescribed Tramadol, taking Oxycodone will only increase your risks. However, if you’re prescribed Oxycodone, you will likely not experience anything additional when also adding Tramadol to the mixture.


It is highly recommended that you never mix these two medications. The results would not be pleasurable or what you desire. Instead, you should only consume your prescribed medication or medications, as recommended.

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David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others. David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.


  1. I have osteoarthritis in both knees back & front its also spreading to other joints eg shoulders,elbows they can’t do any operations for replacements due to copd and heart disease my gp prescribed me Oxycodone hydrochloride it was so helpful I had to take 40 mg am and pm then pain back with vengeance now im on same mg of Oxycodone hydrochloride but now I also take 100 mg tramadol hydrochloride 4 times a day what concerns me the pain in my knees & especially my left shoulder os beyond words its very stiff in a morning and have to use my right jand to move my left arm dors anyone else here have same issues I dont want to ask my gp to increase incase she thinks im abusing meds but I dont think she woll increase due to copd,heart,hyper inflated lungs, and sleep apnea

  2. I take both tramadol and oxyecodon and have done for years now, pain management at the hospital see me every 3 months and I have tried most pain killers but the 2 im on now seem to work best, dose as follows.
    15 mg slow realese oxycodon every 12 hrs
    100 mg of tramadol.every.12 hrs
    40 mg of oxycodon every 4 hrs when needed (most the time)
    Apart from beeing ichie I find it fine

  3. I find Tramadol is helpful when headaches become a side effect of fighting acute cancer pain with OxyContin/oxycodone This seems like different meds are working in different areas of pain : ” Absolutely no medical degree just what works for me “

  4. . REPLY I had been taking Tramadol for about 4 years and I like it. The only side effects I have with it is that I get a bit loopy.
    Then one day I decided that I would just not take any more pain meds….but coming off Tramadol cold turkey will
    bring on some really sick, sick withdrawal symptoms. Don’t do it cold turkey. come off of them cutting the
    daily dosage less and less until you have ;made it. The next time I need pain meds, I will probably take Tramadol, but I
    will be knowing how to come off of them when I need to. There will still be some sick days, even then.

  5. I agree, rather confusing and vague. My wife has had both knees replaced this year and in both instances Tramadol with Tylenol in conjunction with Oxycodone. The Tramadol is for the pain while the oxy. is for “break through” pain; when the Tramadol & Tylenol aren’t enough. The first week of knee replacement the Tramadol wasn’t cutting it alone, we would then take Oxycodone every 4 hours as needed to keep the pain manageable…and you have got to STAY AHEAD of the pain. Don’t wait till the pain is unbearable, be aggressive but not foolish when medicating for the pain. So, with that being said, I don’t understand why they are saying DON’T take these two meds. together when they seem to prescribed together on a rather routine basis.
    So, Anonymous and Andrea, I haven’t had the surgery but I do sympathize with you due to taking care of my wife. Best of luck to you both.

  6. I had a kneereplacement done at 45. U are right the pain is excruciating. They gave me the same thing. But it seemed the pain was so bad especially at night . I feel for your mom God bless her. I had a left hip replacement surgery. It was so different I am pain free. My knee still gives me trouble 3 years later. I was a very active person.

  7. My mom just had a total knee replacement last Wed. She was prescribed Oxycodone and Tramadol so the advice to never mix them is a bit confusing. The pain has been excruciating at times, especially in the night. She has fatty liver disease, so she cannot take any medications with Tylenol, so maybe this is the reason for putting the two together.

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