Tylenol and Nyquil are both popular over-the-counter medications that help you feel better when you have a cold, flu or fever. As these two medicines have different purposes, it’s important to understand the differences and how they should be used.

While the two medicines don’t react with each other in dangerous ways, it’s important to know which one does what so you can use them correctly and avoid any potential side effects. If you take too much of either of these medications, there could be negative side effects. If you take them together, there could also be dangerous interactions between them.

Read on to learn more about taking Tylenol and Nyquil at the same time, as well as how long after taking Tylenol you can take Nyquil.


Tylenol is actually a brand name for acetaminophen, the active ingredient in many over-the-counter pain relievers. You can find it in a variety of different products, including pills, liquid, gels, and even patches. It’s a popular choice because it’s one of the most effective, least expensive pain relievers available.

While Tylenol is most commonly used to treat mild to moderate pain, including headaches and menstrual cramps, it can also help relieve fevers and reduce symptoms of the flu, colds, and coughs. It’s important to note that Tylenol is not an anti-inflammatory and shouldn’t be used to treat joint pains, muscle aches, or other inflammatory conditions.

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What does Tylenol treat?

Tylenol is an over-the-counter medication used to relieve mild to moderate pain, including headaches and menstrual cramps. It also helps reduce fever, reduce symptoms of the flu, colds, and coughs, and treat mild to moderate headaches. Tylenol is not an anti-inflammatory and shouldn’t be used to treat joint pains, muscle aches, or other inflammatory conditions.


Nyquil is a prescription and over-the-counter non-drowsy cold and flu medication. It contains ingredients like acetaminophen, dextromethorphan, and antihistamines that can help you feel better and get some sleep when you’re sick. Nyquil is used to treat the symptoms of a cold or flu, like a stuffy nose or a sore throat. It can also help people get some sleep when they’re sick and possibly avoid missing work or school.

Taking Tylenol and Nyquil together

Taking Tylenol and Nyquil together is generally safe. You should, however, make sure to avoid taking too much acetaminophen as it can damage your liver. If you’re taking both medications, make sure to use the recommended dose of each. Try not to exceed the maximum recommended daily dose of either drug.

With that being said, you should also avoid taking Tylenol and Nyquil with other drugs, including over-the-counter medications and prescription drugs, as they could potentially interact with each other.

How long after taking Tylenol can you take Nyquil?

As with taking the two medications together, it’s important to make sure that there is a gap between taking Tylenol and Nyquil. When taking Tylenol, you should make sure you wait at least two hours before taking any other drug. Wait at least six hours after taking Tylenol before taking Nyquil. The reason for this is that Tylenol is metabolized in the liver. When you take it, your liver metabolizes it and converts it into a toxic chemical called a “metabolite.”

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This metabolite is what does the damage to the liver when you take too much Tylenol. If you take another drug while there is still a toxic metabolite in your liver, it could be metabolized as well, and then go back into your bloodstream. This could cause an overdose of the drug and make you sick.


There are some potential risks associated with taking Tylenol and Nyquil at the same time, although these are generally low. It’s important to make sure you follow the recommended dosing of each medication to reduce any potential risk. When you’re sick, it’s tempting to want to take as many medications as possible to get better.

You should, however, be careful not to go overboard with your medications, as there could be adverse health effects.

David Warren

David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others. David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.