Mucinex and Vyvanse are both medications that are used for different purposes. However, you might be wondering if it is safe to take these two drugs together.

The short answer is no, you cannot take mucinex with vyvanse together. The two drugs have different side effects and can cause you to experience negative reactions if taken at the same time.

Read on to learn more about why you cannot take mucinex with vyvanse and what to do if your doctor has suggested that you take both drugs at the same time.


Mucinex is a medication that is intended to help with coughs, cold, and allergies. It is an anti-inflammatory and expectorant, meaning that it works to reduce the inflammation in your chest and to thin and break up mucus.

One of the reasons why you should not take mucinex with vyvanse is because it is a drug that contains dextromethorphan.

Dextromethorphan is a cough suppressant that can be addictive.

Mucinex may also cause side effects such as upset stomach, vomiting, diarrhea, tiredness, headache, dizziness, and nausea. Rare but serious side effects that can occur from taking mucinex include difficulty breathing, swelling in your throat, or a rash.

These side effects are more likely to occur if you take a high dosage of the drug, if you take it for a long period of time, or if you are pregnant or breastfeeding.

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Vyvanse is a medication that is used to treat attention deficit hyperactivity disorder (ADHD). Similar to how mucinex works for coughs and colds, vyvanse is an anti-inflammatory and a stimulant. It works by increasing the levels of your dopamine and norepinephrine in your brain.

This helps to reduce symptoms of ADHD and improves attention span, focus, and impulse control.

Vyvanse may cause serious side effects, especially if you take too much or if you take it with other medications. Some of the most common side effects of vyvanse are loss of appetite, weight loss, tiredness, nausea, vomiting, and dry mouth.

You may also experience joint or back pain, insomnia, irritability, and mood swings.

Why You Should Not Take Mucinex and Vyvanse Together

The reason why mucinex and vyvanse should not be taken together is that they have different side effects and can cause you to experience negative reactions if taken at the same time.

Vyvanse has a stimulant effect that can make mucinex, which is an anti-inflammatory, less effective.

Taking mucinex and vyvanse together can also cause misdosing issues, which is when a person takes the incorrect amount of a drug.

Mucinex can also cause you to feel more drowsy than normal.

Taking vyvanse with mucinex increases the risk of drowsiness and dizziness, which could become dangerous if you are driving or operating heavy machinery. Mucinex also has a potential to interact with vyvanse, leading to higher amounts of vyvanse in your bloodstream.

Side Effects of Mucinex and Vyvanse

The side effects of mucinex and vyvanse will vary from person to person depending on the person’s health and medical history. However, there are some common side effects that you can expect if you take these medications.

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Here are some of the side effects of mucinex and vyvanse:

  • Mucinex Side Effects:
  • Dry mouth
  • Diarrhea
  • Dizziness
  • Nausea
  • Vomiting
  • Headache

Vyvanse Side Effects:

  • Appetite loss
  • Weight loss
  • Dry mouth
  • Tiredness
  • Nausea
  • Vomiting
  • Joint or back pain
  • Insomnia
  • Irritability
  • Mood swings

Misdosing Issues When Taking Mucinex and Vyvanse Together

Mucinex and vyvanse should not be taken together because there is a high risk of misdosing. This is when a person takes the incorrect amount of a drug and is at risk for negative side effects or serious medical problems.

Mucinex and vyvanse can be taken together, but only if they are taken at different times.

For example, you should always take mucinex at least two hours before or two hours after you take vyvanse. However, taking mucinex and vyvanse together at the same time is not recommended because it increases the risk of misdosing.

Alternatives to Taking Both Medications Together

If you have been prescribed both mucinex and vyvanse and are wondering if you can take them together, you may want to discuss this with your doctor.

Your doctor may be able to prescribe a lower dose of vyvanse or switch you over to a different drug that does not interact with mucinex.

You should also follow your doctor’s instructions exactly when taking these two medications together. This means taking them at different times of the day and in different doses to reduce the risk of misdosing.

Furthermore, if you experience side effects from taking mucinex and vyvanse together, you should contact your doctor immediately. Your doctor can help you manage these side effects and switch you over to a different medication if you are having trouble tolerating these drugs.

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Final Words

Mucinex and vyvanse are different types of drugs that are used to treat different conditions. While these medications may seem like they can be used together, they should never be taken at the same time.

This is because mucinex and vyvanse have different side effects and can cause misdosing issues if taken at the same time.

If your doctor has prescribed mucinex and vyvanse, make sure to follow the instructions for when and how to take them.

You should also watch for side effects and contact your doctor if you experience any issues that are related to taking these drugs.

David Warren

David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others. David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.