Phentermine and Vyvanse are two very different drugs, but they are also frequently taken together. They both have the potential to be effective weight loss aids, but only when used properly as part of a comprehensive plan to achieve and maintain a healthier body.

Many people enjoy the synergistic results of combining these drugs because they reduce hunger while also increasing energy and focus. Both drugs are stimulants that activate the central nervous system, which is why they are most frequently used in combination.

Read on to learn more about the differences between these two drugs and their unique effects on the body.

What is Phentermine?

Phentermine is a prescription appetite suppressant. It works by activating the release of dopamine in the brain.

Dopamine is the neurotransmitter responsible for feelings of pleasure, which is relevant because many people take phentermine for its “”recreational”” properties.

However, phentermine is most commonly used as a weight loss aid because it reduces the amount of calories a person eats.

Phentermine has been approved by the FDA for short-term use in obese people whose BMI is at least 30. It is typically used as a “”bridge”” to help these people lose weight while they work on improving their diet and exercise habits.

Phentermine is available as a tablet, capsule, and extended-release tablet.

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Vyvanse: Adderall’s Shorter, Safer Cousin

Vyvanse is a short-acting stimulant often prescribed for ADHD. It works by increasing neurotransmitters like dopamine, norepinephrine, and glutamate in the brain.

Dopamine is the neurotransmitter responsible for feelings of pleasure and reduced appetite, so Vyvanse has been shown to be effective at reducing the desire to overeat.

Vyvanse is generally a safer option than other stimulants, such as Adderall, because it only lasts for 4-5 hours, while other stimulants have a much longer half-life.

This means Vyvanse will make you feel good, but not high like some other drugs might. Vyvanse is also less likely to cause insomnia, headaches, and stomach pains.

Vyvanse is available as an orange-flavored chewable tablet that dissolves in the mouth.

How to Take Vyvanse and Phentermine Together

Combining Vyvanse and phentermine is not recommended unless you are under the care of a doctor who can monitor your usage.

Doses of Vyvanse and phentermine are usually lower than when taken alone, but side effects like restlessness, anxiety, and irritability can be more common. It is important to remember that these drugs are stimulants and should not be taken when you need to be or are planning to be asleep.

Avoid taking Vyvanse and phentermine before driving a car or operating heavy machinery because it could cause an increase in heart rate and blood pressure.

These drugs can also make certain medical conditions, like high blood pressure and heart disease, worse.

Be sure to talk to your doctor about the best way to take Vyvanse and phentermine together.

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How Vyvanse and Phenter-Combine Works

There are a few ways that Vyvanse and phentermine might work synergistically, and they’re all likely due to the reduced appetite. When you eat less, you’re consuming fewer calories, which is the only way someone can lose weight.

Reducing appetite is also the only way appetite suppressants like phentermine and Vyvanse can work.

So, when you combine the two, you’re getting two effects from one action — you’re eating less. Eating less means you’re consuming fewer calories, which means you’re likely to lose weight.

When used together, these drugs also have another added benefit: they increase energy. More energy means you can be more active and burn more calories.

This is an added benefit, but it’s not the reason the drugs are used together. The reason they are used together is because they help each other be as effective as possible.

Side Effects of Vyvanse and Phentermine Together

The most common side effects of Vyvanse and phentermine together are restlessness, anxiety, irritability, and insomnia.

These are similar to the side effects of each drug taken individually, although the severity may be increased, and the duration may be shorter when the drugs are taken together.

There is also the risk that one or both drugs could become less effective if taken too frequently.

Over time, the body builds up a tolerance to certain drugs, which means that more and more is needed each time to achieve the same effect.

This can be dangerous because it’s easy to overdose once a drug becomes less effective.

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Pros of Vyvanse and Phenter-Combined

This combination can be very effective for short-term weight loss because it helps you to eat less and feel more energized.

Additionally, because it reduces appetite, people often feel less hungry and eat less food when taking Vyvanse and phentermine together.

This effect can last for several weeks after the initial drug cycle ends.

There is also some evidence that Vyvan-combined might help to reverse some of the long-term negative effects of phentermine, including weight gain, in people who have been taking phentermine for a long time.

Cons of Vyvan-Phen Together

This combination can be dangerous because it raises blood pressure more than either drug taken alone and is generally not approved for long-term use.

However, some doctors will prescribe the drugs together for short-term use.

This is typically done for people who need to lose a large amount of weight quickly so that they can meet a specific deadline, such as before an upcoming wedding.

Final Words

Vyvanse and phentermine can be effective weight loss aids when used properly, but they can also be dangerous if not taken under a doctor’s supervision.

These drugs are most commonly used in combination because they reduce appetite while also increasing energy and focus. It is important to remember that these drugs are stimulants and should not be taken before driving a car or operating heavy machinery because they can cause an increase in heart rate and blood pressure.

If you are considering taking Vyvanse and phentermine together, it is important to discuss this with your doctor to make sure it is safe and appropriate for your situation.


David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.