Yes, you can take Xanax and prednisone at the same time. The potential for adverse side effects exists with any medication; however, as long as they are taken in a safe manner, the risk is mitigated.

The combination of these two drugs is sometimes necessary to treat underlying medical conditions.

Read on to learn more about taking xanax with prednisone, including when it’s necessary, what side effects to watch out for and how they should be taken together. Read on to learn more.

What is Xanax?

Xanax is the most common brand name of alprazolam, a type of benzodiazepine (ben-zoe-dye-A-ze-eh-peen). Benzodiazepines are a type of medication used to treat anxiety and panic disorders.

Xanax works by binding to receptors in your brain that are responsible for regulating anxiety, panic, and fear. It essentially reduces the intensity of these emotions and makes it easier to deal with them. It can also be used to treat insomnia and other sleep disorders.

Xanax is the 12th most prescribed drug in the United States, with over 26 million prescriptions being written for it in 2017. It is available as a tablet, extended-release tablet, and injection.

What is Prednisone?

  • Prednisone is a corticosteroid. These medications are used to treat inflammation and autoimmune disorders.
  • Prednisone works by suppressing the body’s immune system, ultimately reducing inflammation and swelling.
  • Prednisone is typically used to treat conditions like asthma, allergies, and autoimmune diseases.
  • Prednisone is a very common drug; it is the second most prescribed drug in the United States.
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Why is Xanax used with Prednisone?

Prednisone can have a number of significant side effects, including insomnia, weight gain, and mood swings. Benzodiazepines can help reduce these side effects by helping with insomnia, anxiety, and irritability.

Xanax is typically used with prednisone to treat autoimmune disorders such as lupus or arthritis. It is also used to treat inflammatory disorders such as psoriasis or asthma. If you have any of these conditions, your doctor may recommend that you take both drugs.

Xanax and prednisone are often used together as short-term treatments to manage anxiety or panic disorders. Benzodiazepines are particularly helpful in the throes of an acute panic attack.

How are Xanax and Prednisone taken together?

Prednisone and Xanax are typically taken together one to two hours apart.
If you are taking both of these medications, be sure to take them at different times of day and with plenty of water.

If you are taking them at the same time, it is important to separate the doses by at least eight hours. If you are taking prednisone in the morning and Xanax in the evening, you should take each drug at least 12 hours apart from each other.

Side effects of taking xanax with prednisone

The most common side effects of taking Xanax with Prednisone include dizziness, drowsiness, and nausea.
If you experience these side effects, you may need to lower your dosage or take smaller doses more frequently.

Prednisone can cause weight gain and mood swings, which is why it is often prescribed with Xanax.

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These two drugs will cause you to gain weight if you do not exercise and eat a healthy diet.
You may also experience mood swings, particularly when you first begin taking these medications. You may feel more irritable and notice mood swings between sadness and irritability.

Overall, taking these two medications together may cause a slight increase in side effects. You may be able to manage these side effects by adjusting your dosage.

Final words: Is it safe to take xanax with prednisone?

Yes, it is safe to take Xanax with Prednisone as long as you are taking the correct dosage for your specific medical condition.

When taking these drugs together, you should be mindful of potential side effects. You may need to adjust your dosage to manage these side effects.

If you experience significant side effects from these medications, you should talk to your doctor. They may recommend that you stop taking one or both of the drugs.


David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.