Omeprazole is a proton-pump inhibitor commonly used to treat stomach ulcers, heartburn, and gastritis. It also has an added benefit of reducing the production of acid in the stomach.

The effects of omeprazole can last for up to 24 hours after you take it. If you take omeprazole regularly, it can cause a decrease in gastric acid production for around 24 hours after taking it.

This means that chemicals that are excreted with excess acid, like xanax and most other common recreational drugs, will linger in your system for much longer than usual when you consume them after taking omeprazole.

These interactions can be very dangerous because they may cause increased side effects or toxicity of those substances. You should avoid consuming any drug while on omeprazole unless your doctor advises you otherwise.

Xanax and Omeprazole

Several drugs like xanax (alprazolam) are broken down in the liver with the help of cytochrome P450 enzymes. These enzymes are also responsible for breaking down omeprazole, but at a much slower rate.

This means that taking omeprazole with xanax will increase the amount of time the xanax is broken down by the liver and thus will stay in your system for a longer period of time.

Because xanax is broken down with the help of cytochrome P450 enzymes, when you take omeprazole with xanax, the xanax will stay in your system for a significantly longer time.

This means that the liver will have to break it down at a much slower rate, resulting in the metabolites of xanax being excreted from the body at a much slower rate as well.

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The half-life of xanax is about 8 hours without omeprazole and about 29 hours with omeprazole.

This means that when you take omeprazole with xanax, the xanax will stay in your system for a total of about 57 hours.

Amphetamine and Omeprazole

Amphetamine is broken down in the liver with the help of cytochrome P450 enzymes. These enzymes are also responsible for breaking down omeprazole, but at a much slower rate.

This means that taking omeprazole with amphetamine will increase the amount of time the amphetamine is broken down by the liver and thus will stay in your system for a longer period of time.

Because amphetamine is broken down with the help of cytochrome P450 enzymes, when you take omeprazole with amphetamine, the amphetamine will stay in your system for a significantly longer time.

This means that the liver will have to break it down at a much slower rate, resulting in the metabolites of amphetamine being excreted from the body at a much slower rate as well.

The half-life of amphetamine is about 2 hours without omeprazole and about 8 hours with omeprazole. This means that when you take omeprazole with amphetamine, the amphetamine will stay in your system for a total of about 10 hours.

Cocaine and Omeprazole

Cocaine is broken down in the liver with the help of cytochrome P450 enzymes. These enzymes are also responsible for breaking down omeprazole, but at a much slower rate.

This means that taking omeprazole with cocaine will increase the amount of time the cocaine is broken down by the liver and thus will stay in your system for a longer period of time.

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Because cocaine is broken down with the help of cytochrome P450 enzymes, when you take omeprazole with cocaine, the cocaine will stay in your system for a significantly longer time.

This means that the liver will have to break it down at a much slower rate, resulting in the metabolites of cocaine being excreted from the body at a much slower rate as well.

The half-life of cocaine is about 1 hour without omeprazole and about 7 hours with omeprazole. This means that when you take omeprazole with cocaine, the cocaine will stay in your system for a total of about 8 hours.

Marijuana and Omeprazole

Marijuana is broken down in the liver with the help of cytochrome P450 enzymes. These enzymes are also responsible for breaking down omeprazole, but at a much slower rate.

This means that taking omeprazole with marijuana will increase the amount of time the marijuana is broken down by the liver and thus will stay in your system for a longer period of time.

Because marijuana is broken down with the help of cytochrome P450 enzymes, when you take omeprazole with marijuana, the marijuana will stay in your system for a significantly longer time.

This means that the liver will have to break it down at a much slower rate, resulting in the metabolites of marijuana being excreted from the body at a much slower rate as well.

The half-life of marijuana is about 1 hour without omeprazole and about 3 hours with omeprazole. This means that when you take omeprazole with marijuana, the marijuana will stay in your system for a total of about 4 hours.

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MDMA (Ecstasy) and omeprazole


MDMA is broken down in the liver with the help of cytochrome P450 enzymes. These enzymes are also responsible for breaking down omeprazole, but at a much slower rate.

This means that taking omeprazole with MDMA will increase the amount of time the MDMA is broken down by the liver and thus will stay in your system for a longer period of time.

Because MDMA is broken down with the help of cytochrome P450 enzymes, when you take omeprazole with MDMA, the MDMA will stay in your system for a significantly longer time.

This means that the liver will have to break it down at a much slower rate, resulting in the metabolites of MDMA being excreted from the body at a much slower rate as well.

The half-life of MDMA is about 2 hours without omeprazole and about 10 hours with omeprazole.

This means that when you take omeprazole with MDMA, the MDMA will stay in your system for a total of about 12 hours.

Conclusion

Taking omeprazole with any of these drugs will cause the metabolites of these drugs to stay in your system for a significantly longer period of time.

This means that the drug will remain in your system longer and thus you will have increased side effects.

You should avoid consuming any drug while on omeprazole unless your doctor advises you otherwise. If you have been prescribed omeprazole and you regularly consume any of these drugs, you should consult with your doctor.

They may advise you to change your treatment plan or offer you an alternative treatment.


David Warren
Author

David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others. David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.