In this article, we will examine the dangers of mixing nyquil and xanax. While these two drugs have different effects on the body, they both are CNS depressants and can result in additive effects when combined together. Both alcohol and opioids also have synergistic effects with these two drugs when combined together. This article explores whether it’s safe to take nyquil with xanax, what the side effects are, and how to avoid negative consequences from combining these substances.

What is Nyquil?

Nyquil is a common over-the-counter medication designed for the relief of symptoms of cold and flu. It’s composed of a combination of sleep-inducing ingredients, including the antihistamine doxylamine, dextromethorphan (DM), and the cough suppressant ethyl alcohol. This last ingredient is responsible for the side effects associated with taking Nyquil, such as drowsiness and dizziness. The recommended adult dosage of Nyquil is one teaspoon, which has about 10 mg of doxylamine, 65 mg of DM, and 40 mg of alcohol.

Xanax: Basics

Xanax is a type of anti-anxiety medication known as a benzodiazepine. Benzodiazepines have long been a popular choice for treating anxiety and have found use in a variety of medical settings, especially those involving patients with mental health disorders. Xanax has a long history of being prescribed for the treatment of anxiety disorders, as well as for the short-term relief of symptoms of panic disorder and insomnia. At low doses, Xanax can be useful for helping people with social anxiety disorder to reduce the symptoms of anxiety and feel more comfortable in social settings. However, high doses of Xanax can be dangerous, even fatal. This is especially true when Xanax is taken in combination with alcohol.

See also  Can You Take Dayquil and Nyquil in the Same Day?

Mixing Xanax and Alcohol

Alcohol is a depressant while Xanax is a stimulant. As a result, mixing them together can have dangerous effects. If a person drinks alcohol while taking Xanax, they could experience dangerously low blood pressure, extreme confusion, or even a coma. Mixing Xanax and alcohol can also result in dangerous interactions with other drugs. This is especially true for opioids, which are commonly prescribed for pain. Mixing alcohol with Xanax and opioids can increase the risk of respiratory failure, coma, and even death.

Mixing Xanax and Benzos

benzos are prescription drugs that are related to Xanax. Mixing Xanax and benzos together can result in dangerous interactions because both are CNS depressants. Mixing Xanax and benzos together can reduce a person’s ability to breathe properly and even cause death in extreme cases.

Mixing Xanax and opiates

Opiates are another type of prescription that is commonly abused. Mixing Xanax and opiates together can be extremely dangerous. Both of these substances are CNS depressants, so they can reduce a person’s ability to breathe. This can result in a fatal overdose.


There are many dangers associated with mixing nyquil and xanax, as well as other prescription drugs. If a person needs assistance with anxiety, it is best to speak with a doctor about the best treatment options. Although anxiety medications exist, there are many dangerous consequences that come with mixing these drugs with other substances. It’s best to avoid mixing these substances together whenever possible.

David Warren

David Warren is a pharmaceutical specialist that dispenses prescription medication on a daily basis. He received a Bachelor of Science degree in pharmacy from the University of Tennessee in 1991. With over 50 publications on medication-related and pharmacy topics, David has been able to share his experiences and knowledge with others. David with lots of experience and knowledge in medications that are utilized to treat a wide range of medical conditions. Before David dispenses a medication to a patient, he will go over the side effects, dosage recommendation and contraindications.


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    I’ve been on 1mg Alprazalom for over 10 years for panic attacks and insomnia​. My new Dr cut me WAY back. From 120 a month to 30 a month. I went days with very little sleep. I ended up in the ER. With Iv meds I was able to come home and sleep. Now it’s been 2 nights without sleep, heading to night three. Is it safe to take zzquil, and not my 1 mg Alprazalom?

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    Dr Pharmacologist

    Actually this information is not accurate. The reason they say you can’t take xanax (alprazolam) with cold meds is because SOME cold meds contain antihistamines that are potentially sedating. Combining xanax with any sedative can result in over-sedation and in extreme cases (usually by taking more than the recommended dosage) this over-sedation can suppress breathing and result in death. This is very very rare and it is much more dangerous to mix xanax and alcohol.
    But many cold meds do not contain sedating antihistamines and in fact contain stimulants such a pseudo ephedrine or phenylephrine. With these types of medication there is almost no risk to combining with xanax and xanax sedating effects will actually be reduced. So for example taking eg pseudofed and xanax together will not cause any problems. Besides most people who take xanax regularly will have significant tolerance to its sedative effects and thus the weak sedating powers of antihistamine cold meds will be virtually nil in comparison to the xanax itself.

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    Omg come on ppl can’t you also include the facts as well as the addiction parts I just need some relief I’m prescribed Xanax can I take nyquil with it gees not everyday just right now iam sick.

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    This is aweful why can’t you put the facts on here as well. you mentioned everything else all I want to know is if it is safe to take together once or maybe twice iam sick not enough to pay a out ragious doctor bill but need something to take and iam on Xanax. I not a addict I just need some relief.

  5. The Team
    The Team

    We are accustomed to receive negative or aggressive comments in the medication mixing section, especilly this one.

    This site is for a large public of profane who want access to the informations quickly without reading hundred of pages, If you have a technical question regarding the biochemistry sensibility of the brain feel free to ask, in the meantime I recommend you to do not to mix xanax and nyquil or similar substance.

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    Your site sucks

    Worst article I have ever read, embarrassed that ‘doctors’ run this site. Just pathetic fear mongering without providing any real information or facts.

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    Same here. I have a kidney stone and bad sinus cold symptoms. I took 1 Xanax that I’m prescribed and trying to see if it’s safe as I also took 15mg of loritab total today but not recently

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    This had to be the worst information ever. I literally searched can I take nyquil and xanax because i have a cold and im a little anxious (not a drug user, i seldomly take any xanax but i do have an perscription) and i find an article that says dont take xanax and nyquil because i will increase my chances of getting addicted and overdosing?!?! Wtf. I only wanted to know is it safe. I did not ask if i have a raging addictive personality is it a good idea to abuse these.

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