Does Metformin Raise Blood Pressure? Exploring the Link and Scientific Evidence3 min read

Metformin is a commonly prescribed medication for managing type 2 diabetes. It helps control blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver.

However, concerns have been raised about whether metformin could potentially raise blood pressure in individuals taking the medication. In this article, we will delve into this topic, examining the scientific evidence and shedding light on the relationship between metformin and blood pressure.

The Link between Metformin and Blood Pressure

Early Concerns

Several studies conducted in the past raised concerns about metformin’s potential to increase blood pressure. Some observational studies suggested a possible association between metformin use and elevated blood pressure levels. However, these findings were limited, and the mechanisms behind the observed increase in blood pressure remained unclear.

Recent Studies

More recent studies have provided valuable insights into the topic, helping to clarify the relationship between metformin and blood pressure.

a) Clinical Trials

A randomized controlled trial published in the Journal of Clinical Endocrinology & Metabolism in 2016 investigated the effects of metformin on blood pressure in patients with type 2 diabetes.

The study found that metformin did not significantly raise blood pressure levels compared to the control group, indicating that metformin is unlikely to have a substantial impact on blood pressure.

b) Meta-Analysis

A meta-analysis published in the Journal of Hypertension in 2019 pooled data from multiple studies to evaluate the effects of metformin on blood pressure. The analysis, which included both observational and interventional studies, concluded that metformin treatment did not lead to a significant increase in blood pressure levels. These findings suggest that metformin is generally safe in terms of blood pressure regulation.

c) Mechanisms of Action

To understand why metformin may not significantly impact blood pressure, it is important to consider its mechanisms of action. Metformin primarily works by reducing glucose production in the liver and improving insulin sensitivity.

Unlike other antidiabetic medications, metformin does not promote weight gain, which is a risk factor for high blood pressure. In fact, metformin is associated with modest weight loss in some individuals, potentially contributing to blood pressure reduction.

Blood Pressure Management

For individuals with type 2 diabetes, blood pressure management is crucial to prevent complications. Metformin’s lack of significant impact on blood pressure levels makes it an attractive choice for those who require both diabetes and blood pressure management.

However, it is essential to note that every individual is unique, and some individuals may experience slight blood pressure changes while taking metformin. Therefore, regular blood pressure monitoring is necessary for patients with diabetes, regardless of the medication they are taking.


Based on the available scientific evidence, it can be concluded that metformin does not significantly raise blood pressure levels in individuals with type 2 diabetes. Recent clinical trials and meta-analyses have shown that metformin treatment does not have a substantial impact on blood pressure.

The mechanisms of action of metformin, such as reducing glucose production and promoting modest weight loss, may actually contribute to blood pressure reduction.

However, it is crucial to remember that individual responses to medication can vary.

Therefore, regular blood pressure monitoring is vital for all individuals with diabetes, irrespective of the medications they are taking.


Study: [Journal of Clinical Endocrinology & Metabolism](link to the study)
Meta-analysis: [Journal of Hypertension](link to the meta-analysis)